The 2016 IEEE International Symposium on Information Theory (ISIT) will be held in Barcelona from 10 to 15 July 2016. This symposium, the premier international conference in information theory, focuses on the presentation of previously unpublished contributions in all of the areas of information theory, including big data analysis, source and channel coding, communication theory and systems, cryptography and security, detection and estimation, networks, pattern recognition and learning, statistics, stochastic processes and complexity, and signal processing. Furthermore, it provides an open forum to discuss and exchange with other researchers on any of these topics.